PDRN + Ectoin Regeneration Serum

Regular price
$55.00
Regular price
Sale price
$55.00
Tax included.
60-Day Results Guarantee

Wake up your skin's natural repair system.

After 40, your skin's ability to heal and regenerate slows down. You need more than surface hydration—you need to reactivate the repair process itself.

Our PDRN + Ectoin Serum does exactly that. Salmon DNA fragments jumpstart cellular repair and collagen production. Ectoin shields cells from environmental stress while strengthening your barrier. Together, they help skin repair efficiently and stay resilient.

No harsh actives that irritate sensitive or thinning skin. Just strengthened foundation and activated renewal—protecting, repairing, and fortifying all at once.

    PDRN + Ectoin Regeneration Serum
    PDRN + Ectoin Regeneration Serum
    PDRN + Ectoin Regeneration Serum
    PDRN + Ectoin Regeneration Serum
    PDRN + Ectoin Regeneration Serum
    PDRN + Ectoin Regeneration Serum
    ☆ Try It 60 Days, Risk Free ☆

    Clinical Actives

    • Salmon DNA (PDRN)

      Salmon-derived DNA fragments that signal your cells to repair damage and produce fresh collagen. Clinically studied for its ability to accelerate skin regeneration and support recovery from environmental stress and inflammation.

    • Ectoin

      Cellular protector that shields skin from UV, pollution, and environmental fluctuants. Strengthens your barrier, locks in moisture, and calms inflammation. Trusted by dermatologists for reactive and sensitive skin.

    • Gluconolactone (PHA)

      Gentle exfoliant that improves texture and radiance without irritation. Attracts moisture while supporting natural cell turnover. Ideal for sensitive or mature skin that can't tolerate traditional acids.

    The Details

    What It Does

    Think of it as hitting reset on your skin's repair capabilities—giving it the support it needs to function at its best.

    What It Does:

    • Activates your skin's natural repair mechanisms
    • Supports collagen production for firmer skin
    • Protects against environmental stress and damage
    • Strengthens and supports barrier function
    • Reduces visible redness and inflammation
    • Use daily, morning and night
    • Gentle enough for sensitive, reactive, or mature skin

    How To Use

    Apply 4-5 drops to clean skin, morning and night. Press gently into face and neck. Wait 1-2 minutes, then layer other products.


    Follow with moisturizer. Use SPF 50 every morning.
    Use daily for best results. This is designed for consistent use—PDRN works as a regenerative signal, so regular application provides cumulative benefits.

    Frequently Asked Questions

    When will I see results?
    Your barrier will feel stronger and more resilient within 2-4 weeks. Visible improvements in texture, firmness, and overall skin function appear around 8-12 weeks. Because this works by signaling your cells to regenerate (not just temporarily plumping), results are cumulative and improve with consistent use.

    Is this safe for sensitive skin?
    Yes. Despite being a powerful regenerative treatment, this serum is formulated specifically for mature, sensitive skin. The ectoin protects your barrier while PDRN works, reducing inflammation and supporting tolerance. Start slowly if your skin is very reactive, but most women experience improved resilience over time.

    How often should I use it?
    Use morning and night for optimal results. This isn't an exfoliating active—it's a regenerative signal, so daily use is not only safe but recommended for cumulative benefits.

    Can I use this with retinoids?
    Absolutely. In fact, we recommend it. Apply this serum first, wait 2 minutes, then apply your retinoid. The barrier support and regenerative signaling help your skin tolerate retinoids better while enhancing results.

    Will this help with post-menopausal skin changes?
    Yes. PDRN has been studied extensively in mature skin for its ability to counteract the slowed fibroblast activity and compromised healing that happens after estrogen decline. It essentially gives your cells the signals they're no longer getting from hormones.

    Can I use this if I have fish or shellfish allergies?
    No. PDRN is derived from salmon. Do not use if you have any fish allergies. Consult your doctor if uncertain.

    What does PDRN feel like on skin?
    Lightweight and fast-absorbing. Some people experience mild tingling on first use as the DNA fragments activate cellular pathways—this is normal and typically diminishes within a week. No stickiness, no pilling, no irritation.

    Can I layer this with other serums?
    Yes. Use this first (on clean skin), wait 2 minutes, then layer other treatments. It enhances penetration and efficacy of products applied after it.

    What are the full ingredients?
    Aqua (water), ethoxydiglycol, propanediol, gluconolactone, sodium benzoate, sclerotium gum, ectoin, glycerine, sodium DNA (PDRN), tetrasodium glutamate diacetate, sodium citrate, potassium sorbate, tocopherol (Vitamin E), citric acid.

    60-Day Results Guarantee

    We believe in what we formulate, so much that we guarantee it.

    Our 60-Day Results Guarantee means you can try Contraire risk-free. If you don't see measurable improvement in barrier strength, hydration, or texture, just reach out. We'll make it right with a no-questions-asked refund.

    Shipping info

    We work hard to get your Contraire products to you quickly.

    All orders ship within 1-2 business days with USPS.

    Feel confident knowing your Contraire journey is backed by our guarantee and seamless shipping experience.

    Loved By Our Community

    Real results from women who get it.

    Our Standards

    • Bottled in the USA

      Formulated and bottled in America with clinical quality standards.

    • Sensitive Skin Safe

      No fragrance, no harsh irritants. Gentle enough for reactive, mature skin.

    • Sustainable Packaging

      Recyclable glass protects formula integrity and reduces plastic waste.

    • Never Tested on Animals

      Cruelty-free formulas tested on women who volunteer their feedback, not animals.

    Customer Reviews

    Based on 23 reviews
    100%
    (23)
    0%
    (0)
    0%
    (0)
    0%
    (0)
    0%
    (0)
    P
    Patricia Green

    Understanding cellular protection becomes more important as we age. This serum addresses both current damage and future prevention beautifully.

    D
    Donna Scott

    My dermatologist suggested looking into ectoin for protection. This formula exceeded expectations for both protection and repair benefits.

    S
    Susan King

    Love the minimal but powerful ingredient list. No unnecessary fillers, just proven actives that work synergistically.

    K
    Kelly Wright

    My skin bounces back faster from environmental stress since using this. The cellular protection is real, not just marketing.

    T
    Tracy Young

    The thought behind this ingredient combination shows. PDRN for repair, ectoin for protection - it's like having a shield and repair crew for your skin.