The science is real. The delivery doesn’t have to hurt.
The Salmon Sperm Facial, also known as a Polynucleotide treatment, utilizes biocompatible proteins derived from fish DNA (commonly salmon sperm) to stimulate cellular healing responses, promote collagen and elastin synthesis, and improve overall skin texture through regenerative properties. The polynucleotide solution is then administered through microinjections using fine needles into the deep dermis via a micro bolus technique, or alternatively with a cannula in the subcutaneous fat for larger treatment areas. The injection process typically takes 30–60 minutes depending on the treatment area. Following injection, the DNA fragments are slowly absorbed into the skin without forming lumps, integrating within the tissue to stimulate fibroblast proliferation, collagen production, and cellular repair mechanisms.
The downside? It has a medi-spa price tag, requires multiple treatments to get collagen production going, leaves your face covered in bumps for the rest of the day, and it isn’t pain-free. Many people report a burning sensation as the polynucleotide solution is injected into the skin—even with numbing cream.
But here’s the good news: you can still get the benefits of PDRN (polydeoxyribonucleotide) without the injections, downtime, or discomfort.
What Is PDRN—and Why Is Everyone Talking About It?
PDRN is a biologically active DNA compound extracted from salmon sperm, known for its remarkable ability to stimulate cell regeneration and accelerate tissue repair. Originally used in medicine to heal wounds, burns, and post-surgical scars, it has quickly made its way into advanced skincare due to its potent ability to:
- Promote fibroblast proliferation (collagen-producing cells)
- Support tissue regeneration and skin barrier repair
- Reduce inflammation, redness, and oxidative stress
- Improve hydration, firmness, and elasticity
- And no—it doesn’t require a needle to work.
Can You Really Use PDRN Topically?
Yes. When formulated correctly, topical PDRN serums can penetrate the skin’s surface and activate many of the same cellular pathways triggered by injectable treatments—without the trauma.
At Contraire, we’ve taken the clinical science behind PDRN and designed a formula that works in your routine, not just in a clinic.
A Needle-Free Alternative That Works
Our PDRN + Ectoin Cellular Regeneration Serum is a topical treatment designed to deliver the regenerative benefits of salmon DNA without requiring injections.
- PDRN stimulates skin repair at a cellular level, improving texture, elasticity, and visible firmness
- Ectoin, a stress-protective molecule, shields skin from environmental damage while supporting hydration and barrier health
- The biomimetic formula mimics your skin’s natural processes, making it safe, effective, and ideal for daily use—even on sensitive skin
- No numbing. No swelling. No post-treatment downtime.
- Just clinical-grade results from the comfort of your home.
Who Is It For?
Topical PDRN is ideal for:
- Skin in your 30s, 40s, and beyond showing signs of fatigue, thinning, or loss of resilience
- Those recovering from over-exfoliation, stress, or environmental damage
- Anyone seeking firming, hydration, and visible rejuvenation without the need for invasive procedures
Final Thoughts
Injectable salmon sperm facials may have captured headlines, but science-backed skincare doesn’t have to hurt—or cost thousands. A well-formulated PDRN serum offers a compelling, non-invasive alternative that works with your biology to restore glow, firmness, and cellular vitality.
You don’t need needles to get results.
You just need ingredients that actually work.
